Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Baron GS"

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EMD-28089

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a22L prion fibril

Release date: Nov. 2, 2022
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8efu
Q-score: 0.462

Hoyt F, Alam P, Artikis E, Schwartz CL, Hughson AG, Race B, Baune C, Raymond GJ, Baron GS, Kraus A, Caughey B

PLoS Pathog (2022) 18 pp. e1010947-e1010947 [ DOI: doi:10.1371/journal.ppat.1010947 Pubmed: 36342968 ]

Sample:

Gpi anchorless underglycosylated 22l prion fibril (Complex from Mus musculus)
Major prion protein (25 kDa, Protein from house mouse)

EMD-25824

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aRML prion fibril

Release date: July 20, 2022
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7td6
Q-score: 0.501

Hoyt F, Standke HG, Artikis E, Schwartz CL, Hansen B, Li K, Hughson AG, Manca M, Thomas OR, Raymond GJ, Race B, Baron GS, Caughey B, Kraus A

Nat Commun (2022) 13 pp. 4005-4005 [ Pubmed: 35831291 DOI: doi:10.1038/s41467-022-30458-6 ]

Sample:

Arml prion (Complex from Mus musculus)
Major prion protein (28 kDa, Protein from house mouse)

EMD-23459

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Infectious mammalian prion fibril (263K scrapie)

Release date: Sept. 1, 2021
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7lna
Q-score: 0.559

Kraus A, Hoyt F, Schwartz CL, Hansen B, Artikis E, Hughson AG, Raymond GJ, Race B, Baron GS, Caughey B

Mol Cell (2021) 81 pp. 4540- [ Pubmed: 34433091 DOI: doi:10.1016/j.molcel.2021.08.011 ]

Sample:

Major prion protein (16 kDa, Protein from Golden hamster)
Infectious mammalian prion fibril (263k scrapie) (Complex from Mesocricetus auratus)

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